Ich hab in letzter Zeit gehoert dass Grapefruit bei Orals die Wirkung steigert. Jetzt ist die Frage stimmt das? und haben hier schon welche erfahrungen damit gemacht?
Grapefruit mit Orals ja oder nein?
- Plattfuss1973
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"GRAPEFRUIT JUICE DRUG INTERACTIONS
This food-drug interaction was actually discovered by accident. A study that was intending to test the interaction of alcohol and a blood pressure medication, used a mixture of alcohol with grapefruit juice to disguise the taste of alcohol for the study. Ironically, alcohol had no effect on the tested medication, but the grapefruit juice seemed to enhance the absorption of the drug. (4)
The researchers then confirmed the finding by comparing drug levels when taken with either grapefruit juice or water and found five-fold higher blood levels of the drug when it was taken with juice. Orange juice did not show this effect.
Grapefruit juice inhibits a special enzyme (CYP3A4) in the intestines that is responsible for the natural breakdown and absorption of many medications. When the action of this enzyme is blocked, the blood levels of these medications increase, which can lead potentially toxic side effects from the medications.
Research has suggested that flavonoids and/or furanocoumarin present in Grapefruit are the substances that act to block the enzyme in the intestines that normally metabolizes many drugs.
Some medications that interact with grapefruit juice: (5)
Statins (Cholesterol Lowering Drugs)
Antihistamines: Terfenadine
Calcium Channel Blockers (Blood Pressure Drugs):
Anti-convulsant: Tegretol (Carbamazepine)
Anxiolytics: Valium (Diazepam)
Anti-depressant: Sertraline Clomipramine
Cortico-steroids: Methylprednisolone
Oestrogens: Ethinyl estradiol
Anabolic Steroids: Dianabol
Impotence Drug: Viagra"
References:
(1) The effects of grapefruit pectin on patients at risk for coronary heart disease without altering diet or lifestyle.
Cerda JJ, Robbins FL, Burgin CW, Baumgartner TG, Rice RW.
Department of Medicine, University of Florida College of Medicine, Gainesville 32610. Clin Cardiol. 1988 Sep;11(9):589-94
(2) Inhibition of atherosclerosis by dietary pectin in microswine with sustained hypercholesterolemia.
Cerda JJ, Normann SJ, Sullivan MP, Burgin CW, Robbins FL, Vathada S, Leelachaikul P.
Department of Medicine, University of Florida College of Medicine, Gainesville.Circulation. 1994 Mar;89(3):1247-53.
(3) A prospective study of tomato products, lycopene, and prostate cancer risk.
Giovannucci E, Rimm EB, Liu Y, Stampfer MJ, Willett WC.
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.J Natl Cancer Inst. 2002 Mar 6;94(5):391-8.
(4) Grapefruit juice-drug interactions.
Bailey DG, Malcolm J, Arnold O, Spence JD.
Department of Medicine, London Health Sciences Centre, Ontario, Canada.Br J Clin Pharmacol. 1998 Aug;46(2):101-10. .
(5) http ://secure.pharmacytimes.com/lessons/200303-02.asp______________________________________________________________________________________________________________________________________________________
"Can grapefruit juice influence ethinylestradiol bioavailability?
Weber A, Jager R, Borner A, Klinger G, Vollanth R, Matthey K, Balogh A.
Department of Clinical Pharmacology, Friedrich Schiller University of Jena, Germany.
The effects of grapefruit juice on the bioavailability of 17 alpha-ethinylestradiol (EE2) after a single oral administration of 50 micrograms EE2 have been investigated. The pharmacokinetics of EE2 were studied in an open, randomized, cross-over study in which 13 healthy volunteers were administered the drug with herbal tea or grapefruit juice (naringin, 887 mg/ml). In contrast to herbal tea, grapefruit juice increased the peak plasma concentration (Cmax) significantly to 137% (mean; range 64% to 214%, p = 0.0088) and increased the area under plasma concentration-time curve from 0 to 8 hours (AUC0-8) to 128% (mean; range 81% to 180%, p = 0.0186). This study shows that grapefruit juice increases the bioavailable amount of EE2. A possible explanation may be that grapefruit juice inhibits the metabolic degradation of EE2. Whether the increased bioavailability of EE2 following grapefruit juice administration is of clinical importance should be investigated in long-term studies.
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Das habe ich auch gelesen. Die wichtige Frage ist jetzt nur machen dass BBler? oder ist es zu krass?
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Hier gibt es eine Abstimmung. Anscheinend machen es viele. Grapefruitsaft: Kann man Dopingmittel dopen?
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