Pramipexole lowers prolactin and raises HGH in a dose dependant relationship so the more you take the more it works.
Neuroendocrine and side effect profile of pramipexole, a new dopamine receptor agonist, in humans.
Schilling JC, Adamus WS, Palluk R.
Human Pharmacology Centre, Boehringer Ingelheim KG, Germany.
The effects and tolerability of pramipexole, a new dopamine D2-receptor
agonist, on prolactin, human growth hormone, thyrotropin, cortisol, and
corticotropin levels were investigated in a randomized, double-blind,
crossover study in 12 healthy volunteers. Single oral doses of 0.1, 0.2,
and 0.3 mg pramipexole and placebo were studied over a period of 24
hours. Pramipexole decreased serum prolactin levels in a
dose-dependent manner, with a maximum effect after 2 to 4 hours. Serum
levels of human growth hormone were dose-dependently increased; however,
this effect was only significant 2 hours after drug administration.
Furthermore, a slight increase in serum cortisol levels and a slight
decrease in serum thyrotropin levels was observed. Our findings show for
the first time pharmacodynamic effects of pramipexole after single oral
doses in healthy volunteers. The compound was well tolerated and showed
an endocrine profile similar to other dopamine D2-agonists.
PMID: 1350237 [PubMed - indexed for MEDLINE]