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[Saarland1983]

Hallo Leute,

kann mir mal bitte jemand sagen ob das Steroide sind, die in diesen Produkten enthalten sind? Wenn ja welche, wenn nein was ist das?





vielen Dank im Voraus..

Gruß

[Stinktier]

5-AT (5-androstene-3 beta, 7 beta, 17 beta-triol) = b-Androstenetriol



Androstenetriol:An Interesting DHEA Metabolite
by Thomas Incledon, PhD(c), RD, LD/LN, RPT,NSCA-CPT, CSCS

In this article, I will dig deep into the research and present all of the current scientific information on androstenetriol.While things may get a little technical, don?t split your Speedos. I?ll spell it out in simple terms and you will understand all that the scientists know.

Which is the real androstenetriol?
Triols are simply steroids with three hydroxyl (OH) groups attached to their carbon structures. After reviewing through every study I could find, it appears that there are at least 3 possible androstenetriols:
1) 5-androstene-3 beta, 16 alpha, 17 beta-triol
2) 5-androstene-3 beta, 7 alpha, 17 beta-triol
3) 5-androstene-3 beta, 7 beta, 17 beta-triol
All of these agents are structurally classified as steroids.The first one has been isolated from human placenta and can be converted into the estrogen estriol [1].This 16 alpha-androstenetriol version was first isolated from the urine of a patient with cancer of the adrenal glands in 1943 and was later identified in human umbilical plasma [2] and also isolated from the urine of infants [3] and men [4].There isn?t much known about the function of this triol. It appears to inhibit the enzyme 16-alpha hydoxylase [5] and can be produced from DHEA by human macrophages (specialized white blood cells) [6]. Until more is learned about this agent, it would be best to avoid the 16 alpha-androstenetriol version.

The second and third versions of androstenetriol are basically isomers of each other. They have the same chemical formula, but the difference is in the orientations of the hydroxyl groups attached to the 7th carbon. Most of the research appears to be on the 7-beta androstenetriol, so this will be the focus of this article and from here on referred to as androstenetriol.

Synthesis of androstenetriol (5-androstene-3 beta, 7 beta, 17 beta-triol)
Research using abdominal skin from men and women indicates that androstenetriol can be formed from two separate pathways [7]. First, DHEA can be converted into 5-Androdiol (5AD or 5-androstene-3 beta, 17 beta-diol). 5AD in turn can be converted into androstenetriol (5AT). 5AT can also be formed from the 7-keto version of 5AD.To make this easier to follow here is a chart:
DHEA
5-androstene-3 beta, 17 beta-diol (5AD)
5-androstene-3 beta, 7 beta, 17 beta-triol (5AT)
and/or
5-androstene-3 beta, 17 beta-diol (5AD)
5-androstene-3 beta, 7 alpha, 17 beta-triol
7-keto-5-androstene-3 beta, 17 beta-diol
5-androstene-3 beta, 7 beta, 17 beta-triol (5AT)
The arrows indicate which way the reactions can proceed.The synthesis of 5AT comes primarily from the direct conversion of 5AD to 5AT. Since both 5AD and 5AT can come from DHEA, they are referred to as DHEA metabolites in the literature, hence the title of this article.

A Little 5AT History
It was established that DHEA could counteract the effects of glucocorticosteriods (like cortisol) and boost immunity [8]. Later after realizing that DHEA could be metabolized by skin and brain into 5AD and 5AT [9, 10], researchers started to investigate the DHEA metabolites. In vitro studies with mice lymphocytes (specialized white blood cells) indicated that 5AT strongly counteracted cortisol and boosted lymphocyte activity, whereas DHEA did not counteract cortisol and suppressed lymphocyte activity [11]. Additional in vitro studies demonstrated that 5AT was more effective against a viral infection in mice than its precursor 5AD [12]. 5AT potentiated immune responses and counteracted the immunosuppressive actions of cortisol.The researchers also found that the 7-beta version of 5AT was more potent than the 7-alpha version of 5AT.

Immune Boosting Effects of 5AT
Traditionally when we learn or discuss the immune system, it is treated as a separate physiological system from the endocrine and nervous systems. In 1988 Loria et al reported that DHEA could regulate immune responses against lethal virus and bacterial infections [13].Over the next two decades, scientists started piecing together a process that involved components of the nervous system, endocrine system, and immune system. 5AT appears to have a dose response effect. Using mouse spleen cells and concentrations ranging from 5 nanomoles per liter to 5 micromoles per liter, 5AT stimulated the production of the cytokines interleukin-2 (IL-2) by 111-122% and interleukin-3 (IL-3) by 30-47% [12].T-cells and B-cells were also simulated by this DHEA metabolite. In other studies using mouse macrophages, 5AT increased tumor necrosis factor alpha (TNFalpha) and IL-1 secretion while not influencing IL-6 production [14].
The data I have reviewed thus far is all from rodents (particularly mice). Since 5AT boosts the immune system of rodents, one asks the logical question: can this data also be applied to humans? Since 5AT is present in a variety of mammals, including humans, it seems plausible that 5AT could boost the immune response in humans.This needs to be confirmed by research and questions as to how much is needed in humans to get a decent effect need to be answered.

Antiglucocorticoid Effects of 5AT
DHEA and its metabolites (5AD and 5AT) counteract the stress-induced immunosuppressive action of glucocorticoids [15].This results in stronger responses to immune system challenges. Hydrocortisone (cortisol) classically is used to suppress immune function in cells treated with an immune challenge. DHEA was unable to counteract the immunosuppressive effects of cortisol, while 5AD counteracted it only at high doses. 5AT significantly counteracted the immunosuppressive effects of the glucocorticoid on lymphocyte growth and cytokine production [15]. Research overall indicates that in the body,DHEA, 5AD, and 5AT may have some similar functions, while in cell culture studies their effects are dramatically different from one another. In another study, 5AT counteracted the down-regulatory effect of hydrocortisone on macrophages and may function to counterbalance glucocorticoid function [14].
An abstract was presented in 1997 at the Conference on Cortisol and Anti-Cortisols in Las Vegas Nevada. In vitro work indicated that 5AT counteracted the immunosuppressive effects of glucocorticoids on immune cells from patients with hypercortisolemia [16]. This data is preliminary and has yet to be published (or is not indexed on any database I searched through).

Looking Ahead
So far we have a bunch of rodent studies with some preliminary evidence from sick humans that 5AT can counteract cortisol and boost immune responses. Can 5AT counteract the effects of cortisol on skeletal muscle? We have no clue right now. We don?t know how 5AT does its job. It may turn out to act through a pathway specific to immune cells, or on the other hand, a common pathway for a variety of cells. One thing that was clear from the literature is that 5AT counteracts the losses of tissue weight due to excess glucocorticoid. It is too early to extrapolate this to healthy people as a means of gaining weight. It could be extrapolated to say that 5AT may prevent loss of immune spleen and thymus tissue weights during a sever infection. Could this have potential application for bodybuilders and athletes? The obvious application would be to marathon runners, triathletes, and wrestlers who are traditionally overtrained. I am working on some projects right now and hope to have a definitive answer in the future as to how Androstenetriol can be used by athletes. Keep reading ASMJ and you?ll be the first to know.

References
1. Ryan, K.J., Conversion of delta 5-androstene-3 beta, 16 alpha, 17 beta-triol to estriol by human placenta. Endocrinology, 1958. 63: p. 392-394.
2. Colas, A.,W.L. Heinrichs, and H.J. Tatum, Pettenkofer chromogens in the maternal and fetal circulations:
Detections of 3 beta, 16 alpha, dihydroxy-androst-5en-17 -one in umbilical cord blood. Steroids, 1964. 3(4): p. 417-434.
3. Reynolds, J.W., The identification and quantification of delta-5-androstenetriol (3-beta, 16-alpha, 17-betatrihydroxyandrost-5-ene) isolated from the urine of premature infants. Steroids, 1966. 8(5): p. 719-727.
4. Fotherby, K.,The isolation of 3 beta-hydroxy-delta 5- steroids from the urine of normal men. Biochemical Journal, 1958. 69: p. 596-600.
5. Sano,Y., et al., Steroid 16 alpha-hydroxylase from human fetal liver; inhibition by steroids.Acta Obstetricia et Gynecologica Scandinavica, 1980. 59(3): p. 245-249.
6. Schmidt,M., et al.,Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages. Journal of Endocrinology, 2000. 164(2): p. 161-169.
7. Faredin, I. and I.Toth,The metabolism of [4-14C]5-androstene-3beta, 17beta-diol by normal human skin in
vitro.Acta Medica Academiae Scientarum Hungaricae, 1975. 32(2): p. 139-152.
8. Loria, R.M. and D.A. Padgett, Mobilization of cutaneous immunity for systemic protection against infections. Annals of the NewYork Academy of Sciences, 1992. 650: p. 363-366.
9. Akwa, Y., et al., Neurosteroid metabolism. 7 alpha-Hydroxylation of dehydroepiandrosterone and
pregnenolone by rat brain microsomes [published erratum appears in Biochem J 1993 May 1;291(Pt 3):952]. Biochemical Journal, 1992. 288(Pt 3): p. 959-964.
10. Mathur,C., et al., Steroids and their conjugates in the mammalian brain. Proc Natl Acad Sci U S A, 1993. 90(1): p. 85-88.
11. Padgett, D.A. and R.M. Loria, In vitro potentiation of lymphocyte activation by dehydroepiandrosterone,
androstenediol, and androstenetriol. Journal of Immunology, 1994. 153(4): p. 1544-1552.
12. Loria,R.M.,D.A. Padgett, and P.N. Huynh,Regulation of the immune response by dehydroepiandrosterone and its metabolites. Journal of Endocrinology, 1996. 150(Suppl): p. S209-S220.
13. Loria, R.M., et al., Protection against acute lethal viral infections with the native steroid dehydroepiandrosterone (DHEA). Journal of MedicalVirology, 1988. 26(3): p. 301-314.
14. Padgett, D.A. and R.M. Loria, Endocrine regulation of murine macrophage function: effects of
dehydroepiandrosterone, androstenediol, and androstenetriol. Journal of Neuroimmunology, 1998. 84(1): p.
61-68.
15. Loria, R.M.,Antiglucocorticoid function of androstenetriol. Psychoneuroendocrinology, 1997. 22(Suppl 1): p. S103-S108.
16. Norbiato, et. al. In Vitro Immunomodulatory Effects of Delta 5-Androstene-3b, 7b,17b Triol (AET) in Hypercortisolemic Patients. In: Conference on Cortisol and Anti-Cortisols. 1997. LasVegas, NV.

[Stinktier]

tja saarland, damit hast du unsere wette leider verloren. 5-At wird als steroid klassifiziert.

ich werd mir das kilo eiweisspulver schmecken lassen.

[Saarland1983]

ICH WURDE REINGELEGT!

Man sagte mir das wäre "natürlich".. .. unfair!

[Stinktier]

Dopingliste

Die Dopingliste (Liste verbotener Substanzen im Sport) ist ab dem 1. Januar 2008 gültig. Wie durch die WADA vorgegeben werden die Stoffe mit ihren Englishen Namen gelistet:

Diese in der Dopingliste aufgeführten Substanzen sind verbotene Dopingmittel bzw. verbotene Medikamente. Die jeweils aktuellste Version der Doping Liste Kann bei der WADA heruntergeladen werden. In dieser Liste sind nicht die verbotenen Praktiken wie Blutdoping aufgeführt. Wenn einer dieser Stoffe bei einer Dopingkontrolle festgestellt wird, wird dies als verbotene Medikation gewertet. Ob dies bei einem Wettbewerb oder im Training passiert ist dabei irrelevant.

Anabole Steroide:

1-androstendiol (5α-androst-1-ene-3β,17β-diol )
1-androstendione (5α- androst-1-ene-3,17-dione)
bolandiol (19-norandrostenediol)
bolasterone
boldenone
boldione (androsta-1,4-diene-3,17-dione)
calusterone
clostebol
danazol (17α-ethynyl-17β-hydroxyandrost-4-eno[2,3-d]isoxazole)
dehydrochlormethyltestosterone (4-chloro-17β-hydroxy-17α-methylandrosta- 1,4-dien-3-one)
desoxymethyltestosterone (17α-methyl-5α-androst-2-en- 17β-ol)
drostanolone
ethylestrenol (19-nor-17α-pregn-4-en-17-ol)
fluoxymesterone
formebolone
furazabol (17β-hydroxy-17α-methyl-5α- androstano[2,3-c]-furazan)
gestrinone
4-hydroxytestosterone (4,17β- dihydroxyandrost-4-en-3-one)
mestanolone
mesterolone
metenolone
methandienone (17β-hydroxy-17α-methylandrosta-1,4-dien-3-one)
methandriol
methasterone (2α, 17α-dimethyl-5α-androstane-3-one-17β-ol)
methyldienolone (17β-hydroxy-17α-methylestra-4,9-dien-3-one)
methyl-1- testosterone (17β-hydroxy-17α-methyl-5α-androst-1-en-3-one)
methylnortestosterone (17β-hydroxy-17α-methylestr-4-en-3-one)
methyltrienolone (17β-hydroxy-17α-methylestra-4,9,11-trien-3-one)
methyltestosterone
mibolerone
nandrolone
19-norandrostenedione (estr-4-ene-3,17-dione)
norboletone
norclostebol
norethandrolone
oxabolone
oxandrolone
oxymesterone
oxymetholone
prostanozol ([3,2-c]pyrazole-5α-etioallocholane-17β-tetrahydropyranol)
quinbolone
stanozolol
stenbolone
1-testosterone (17β-hydroxy-5α-androst-1-en-3- one)
tetrahydrogestrinone (18a-homo-pregna-4,9,11-trien-17β-ol-3-one)
androstenediol (androst-5-ene-3β,17β-diol)
androstenedione (androst-4-ene- 3,17-dione)
dihydrotestosterone (17β-hydroxy-5α-androstan-3-one)
prasterone (dehydroepiandrosterone, DHEA)
5α-androstane-3α,17α-diol
5α-androstane-3α,17β-diol
5α-androstane- 3β,17α-diol
5α-androstane-3β,17β-diol
androst-4-ene-3α,17α-diol
androst-4-ene-3α,17β-diol
androst-4-ene-3β,17α-diol
androst-5-ene- 3α,17α-diol
androst-5-ene-3α,17β-diol
androst-5-ene-3β,17α-diol
4-androstenediol (androst-4-ene-3β,17β-diol)
5-androstenedione (androst-5- ene-3,17-dione)
epi-dihydrotestosterone
3α-hydroxy-5α-androstan-17- one
3β-hydroxy-5α-androstan-17-one
19-norandrosterone
19- noretiocholanolone

Hormone

Erythropoietin (EPO)
Growth Hormone (hGH)
Insulin-like Growth Factors (e.g. IGF-1)
Mechano Growth Factors (MGFs)
Gonadotrophins (e.g. LH, hCG), prohibited in males only
Insulins
Corticotrophins

Sonstiges

Anastrozole
Letrozole
Aminoglutethimide
Exemestane
Formestane
Testolactone
Raloxifene
Tamoxifen
Toremifene
Clomiphene
Cyclofenil
Fulvestrant

Verschleiernde Mittel

Acetazolamide
Amiloride
Bumetanide
Canrenone
Chlorthalidone
Etacrynic acid
Furosemide
Indapamide
Metolazone
Spironolactone
Thiazides (e.g. bendroflumethiazide, chlorothiazide, hydrochlorothiazide)
Triamterene

Eine Garantie auf die Vollständigkeit und Richtigkeit der Liste der Verbotenen Stoffe und Medikamente im Sport kann nicht gegeben werden. Bitte informieren Sie sich dafür direkt bei der WADA.

[Stinktier]

steht sogar auf der dopingliste.

[Saarland1983]

5α-androstane-3β,17β-diol = wie 5-etioallocholen-3b,7b,17b-triol ??? hmm?!

Könnte ja noch jemand anderes was dazu schreiben

[Stinktier]

gebs auf saarland, du wurdest überführt.

[redman25]

diol ist nicht triol.
5-at ist steroidal aber nicht androgen.

soweit ich weiß stand 5-at selbst bei der gnbf bis vor kurzem nicht unter verbot. sollte sich das geändert haben ändert das nichts daran, dass es sich nicht um ein anaboles und androgens steroid hält sondern um einen nicht androgenen dhea-metabolit.

[bersi]

Ich würd generell die FInger von dem Mist aus den USA lassen. Generell ist da alles billig aber bei denen steht sogar geshcmackt über Qualität

[Stinktier]

ich hab saar auch gesagt, dass er da nichts schlimmes red und du ihm nichts schlimmes empfohlen hast.

die wette bleibt dank 5-AT trotzdem verloren.

[redman25]

das auf deiner dopingliste ist aber nicht 5-at. das ist ein -diol und 5-at ist ein triol. du hast den falschen stofff gehighlighted

[Saarland1983]

.. er bekommt sein eiweiss .. ist doch okay.. habe ich eben verloren..

[Saarland1983]

ICH WURDE REINGELEGT!

Man sagte mir das wäre "natürlich".. .. unfair!

saar du bist so Cool Bruder,
ich liebe dich

[derpa]

Wo hast du dass denn her?

[Saarland1983]

von gigas... beides driven sports produkte, einmal Triazole und einmal lean xtreme..

[abuleh]

von gigas... beides driven sports produkte, einmal Triazole und einmal lean xtreme..

Das Lean Xtreme habe ich schön öfters in der Diätphase verwendet. Ich hatte einen ganz guten Eindruck davon und es hat die Fettverbrennung unterstützt sowie Cortisol unterdrückt!

~abuleh

[snickers]

des macht mich jetzt aber neugierig ....kann noch jemand was zu diesen army produkten was sagen?

[abuleh]

des macht mich jetzt aber neugierig ....kann noch jemand was zu diesen army produkten was sagen?

Wieso Army Produkte?

[dSh]

Er meinte bestimmt Amerikanische Produkte